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One of the most popular museums in the Colonial City is also its most impressive in architecture. Completed around 1512, this Gothic and Renaissance style palace was once the home of Diego Columbus, son of Christopher Columbus, and his wife María de Toledo, niece of King Ferdinand of Spain. With views overlooking Plaza de España on one side, and the Ozama River on the other, it is the oldest vice regal residence in the Americas, and the first fortified palace, turned into a museum showcasing 16th century furniture, art, musical instruments, and weapons. Winding staircases lead towards the couple’s well-preserved bedrooms, and to the lavish crystal chandelier-lit reception hall where events were hosted for the Spanish aristocracy.